Her father, Joel Bamford, was serving as a Navy doctor. Maria Bamford was born on September 3, 1970, at the Port Hueneme Naval Base in Port Hueneme, California. She voiced Tito, the Anxiety Mosquito, in Big Mouth.

The 2016 Netflix original series Lady Dynamite, in which she plays the lead role, is based on her life. In 2014, she won the American Comedy Award for Best Club Comic. Her live television work began in Louie (2012), Arrested Development (2013–2019), WordGirl (2007–2015), Big Mouth (2017–present), and Human Resources (2022–present). She voices Talking Ginger and Talking Becca in the Talking Tom and Friends web series.

Her film work includes Stuart Little 2 (2002), Charlotte's Web 2: Wilbur's Great Adventure (2003), Barnyard (2006), Heckler (2007), and Hell and Back (2015). One of her first feature films is Lucky Numbers (2000), and she voiced characters on many animated shows, including Shriek on CatDog, and many more on American Dad!, Ugly Americans, Adventure Time, and BoJack Horseman. Her first comedy album and tour was The Burning Bridges Tour (2003), followed by eight more albums and specials. Her work has drawn critical acclaim and controversy because her humor often uses self-deprecating and dark topics, including her dysfunctional family, depression, anxiety, suicide, and mental illness. Maria Bamford (born September 3, 1970) is an American actress and stand-up comedian.

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